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Newer concepts in silica and silicate lung disease.
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1160-1161
Results obtained through a series of autopsy lung studies from a group of Cornish china clay workers were presented. The industry began in the eighteenth century when china clay and china stone deposits were worked and the products used in British pottery production. There was good agreement obtained between the occupational histories and the mineral content of the lungs. Nodular fibrosis correlated better with quartz (14808607) concentrations than kaolinite (1318747). Interstitial fibrosis correlated better with kaolinite concentration than nodular fibrosis. In the majority of cases it was relatively easy to separate the china clay cases from the china clay and china stone cases histologically. The author concludes that a pneumoconiosis may result from nonfibrous silicates in the absence of free silica (7631869), in this case kaolin (1332587), and interstitial fibrosis is the predominant lesion. Further studies of this type are needed to understand the toxic effects of free silica and nonfibrous silicates on the human lung.
Occupational exposure; Airborne dusts; Mineral dusts; Dust inhalation; Coal dust; Silica dusts; Tissue distribution; Body burden; Lung burden
14808-60-7; 1318-74-7; 7631-86-9; 1332-58-7
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
Page last reviewed: June 15, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division