Element analyses in human lung tissue correlated with smoking, emphysema and lung cancer.
Kalliomaki-PL; Paakko-P; Kokkonen-P; Anttila-S; Kalliomaki-K
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Nov; (Part II):1083-1086
An investigation was conducted to determine the concentrations of light elements derived mainly from minerals, heavy metals and essential trace elements in human lung tissue. The elemental concentrations observed in lung tissue were related to smoking, emphysema, and lung cancer. The lung specimens were collected from subjects without any malignant disease and from lung cancer patients. The concentrations of magnesium (7439954), titanium (7440326), chromium (7440473), and cadmium (7440439) were higher in the surgical specimens of lung cancer patients than in autopsy lung tissue of nonmalignant subjects. The severity of emphysema was related to the increase of the concentrations of calcium (7440702), cadmium and chromium. The moderate and severe emphysema was related to the decrease of the concentration of copper (7440508) and iron (7439896). In lung tissue of nonmalignant autopsy lungs the effect of severity of emphysema was more prominent. A positive correlation, but not statistically significant, was noted between the concentrations of chromium and cadmium and smoking time in the nonmalignant autopsy lungs of the current smokers. The surgical specimens revealed no significant trend in the concentration of any element as a function of smoking time. The concentration of cadmium was significantly decreased in lung tissue of exsmokers in both groups. A relative correlation was noted between nonsmoking years and the cadmium lung content among exsmokers. The concentration of chromium was slightly higher in the lung tissue of exsmokers than in that of current smokers.
Body-burden; Tissue-distribution; Lung-burden; Chemical-analysis; Cigarette-smoking; Mineral-dusts; Respiratory-system-disorders; Dust-inhalation
7439-95-4; 7440-32-6; 7440-47-3; 7440-43-9; 7440-70-2; 7440-50-8; 7439-89-6
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA