The Effect of Tachykinin Depletion on Hydrogen Sulphide Toxicity in Rats.
Green-FH; Lopez-A; Prior-M; Balu-A; Butt-J
NIOSH 1990 Sep:607-617
A study was made of the effects of hydrogen-sulfide (7783064) (H2S) in animals previously depleted of substance-P and focused on the pathophysiology of the airway lesions. A comparison was made of the histological changes induced in the lungs of the Fischer-344-rats exposed to H2S with the changes observed in the lungs of humans following fatal exposures to H2S. Animals exposed to H2S without capsaicin pretreatment had a 20% mortality at an average concentration of 542mg/m3. Animals pretreated with capsaicin and exposed to the same concentration of H2S demonstrated 100% mortality. The animals also died at an earlier time during exposure than animals pretreated with saline and then exposed to H2S. Those pretreated with capsaicin also suffered more severe pulmonary edema with a greater concentration of protein in the lavage fluid and heavier lungs postmortem. The airway lesions noted in the H2S exposed rats were similar to those reported for sulfur-dioxide (7446095). The lesions were most severe in the proximal airways with relative sparing of the bronchioles and alveolar ducts. An unexpected result was the demonstration of a potentiating effect of neuropeptide depletion on H2S induced airway injury.
Toxic-gases; Cell-damage; Lung-cells; Sulfides; Cell-function; Laboratory-animals; Respiratory-system-disorders; Lung-disease; Inhalation-studies;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference