Effects of Antioxidants on Experimental Silicosis.
NIOSH 1990 Sep:582-591
An investigation was conducted to gain some insight into the protective effects of antioxidant agents on experimentally induced silicosis in male rats. Selenium, vitamin-A and vitamin-E as well as their combinations acted mainly on the course of inflammatory events preceding fibrosis, by trapping the formed free radicals and thereby preventing lipid peroxidation. Zinc impaired mainly collagen synthesis and processing. These results confirmed previously reported protective effects of zinc with respect to induced effects of quartz (14808607) exposure. The results also supported the hypothesis that the peroxidative damage is important as an additional role in the fibrotic action of quartz dust. One of the most significant observations was that under antioxidant treatment, silicotic fibrosis diminished. The authors conclude, therefore, that given correct concentrations, these antioxidants appear to be beneficial as prophylactic and therapeutic agents in silicosis. The applicability of these methods to humans can only be speculative at this time.
Tissue-distribution; Body-burden; Fibrous-bodies; Cell-damage; Dust-exposure; Silica-dusts; Lung-cells; Coal-dust; Cell-function; Laboratory-animals; Respiratory-system-disorders; Protective-measures;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference