The Pulmonary Toxicity of Mixed Dust Is Not Only Related to Its Mineralogical Composition.
Wastiaux-A; Daniel-H; Sebastien-P
NIOSH 1990 Sep:576-581
Two samples of coal dust having the same bulk mineralogical composition in terms of coal, quartz (14808607), illite (12173603), and kaolin (1332587) were examined to determine their effect on lung function in female Wistar-rats. The rats received a single intratracheal injection of 60 milligrams of fine particles suspended in 1 milliliter of saline. The animals were sacrificed 12 or 24 months after exposure. The mean weight of fresh lung and mean collagen content of the lung were both above corresponding control values, with the highest figures measured at month 24. The collagen content of the lung was more than three times higher with the reconstituted mixture than with the Aumance coal dust. Lesions were present in the lungs of exposed animals. A very high proportion of the injected dust was noted in the lung at month 12 and at month 24. Quartz accounted for 17% of the injected dust, but the proportions of quartz in the lung dust were less than the other substances. Analytical Transmission Electron Microscopic (ATEM) analysis of dust used for injection indicated the presence of very fine particles in both samples. Most of the particles observed by ATEM were less than 2.5 micrometers in apparent Ferret's diameter. Particles extracted from the lung at month 24 were either isolated or grouped into large agglomerates. Such agglomerates were not detected in the injected dust.
Tissue-distribution; Body-burden; Mineral-dusts; Fibrous-bodies; Cell-damage; Dust-exposure; Silica-dusts; Lung-cells; Cell-function; Laboratory-animals; Coal-dust; Respiratory-system-disorders;
14808-60-7; 12173-60-3; 1332-58-7;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference