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The deposition of fibers and spheres at the carina in excised lungs.
Esmen NA; Kahn RA
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Part I):571-575
An investigation was conducted to comparative deposition of fibers and spheres at the carina in an effort to provide valuable insight into the deposition of fibers in the tracheobronchial system. Nearly monodispere, size classified glass spheres and glass fibers were prepared. Twenty nine pneumonia free calf lungs were obtained at the time of slaughter. The lungs were exposed for about 20 minutes to the prepared dust. The trachea was sliced into two sections for analysis of deposited particles. The authors conclude that this method for evaluating particle deposition at the carina in excised lungs can be used to investigate the influence of sedimentation, interception and diffusion on fiber removal. Altering the physical properties of the particles and/or the tracheal velocities should provide suitable conditions to derive empirical relationships defining the interplay of particle and airflow characteristics and removal efficiencies via these other deposition mechanisms. By choosing several large fiber sizes of equal impactive potential but of dramatically different length, the deposition enhancement by interception may be investigated.
Tissue distribution; Body burden; Airborne dusts; Fibrous bodies; Cell damage; Dust exposure; Silica dusts; Lung cells; Cell function; Laboratory animals; In vitro study
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA
Page last reviewed: June 15, 2021
Content source: National Institute for Occupational Safety and Health Education and Information Division