Analysis of fatty acids fractions of phospholipids and neutral lipids from bronchoalveolar lavage fluid (BALF) in patients with occupational lung disease (OLD).
Duarte-G; Fonseca-E; Araujo-A; Costa-ME
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-108, 1990 Sep; (Part I):452-458
An investigation was conducted of the lipidic composition (phospholipids, neutral lipids and fatty acids) of the extracellular compartment of the pulmonary surfactant, obtained through bronchoalveolar lavage in 15 individuals: five normal, five pigeon breeders, and five silicosis patients. The examination of the phospholipids revealed some differences in both groups of patients in relation to comparisons. A significant decrease of phosphatidylcholine was noted in pigeon breeders as well as phosphatidylglycerol in silicosis patients. In both groups there were significant increases of phosphatidylethanolamine and sphingomyelin. An important decrease of C16:0 and increase of fatty acids saturated in C16, C18, and C20 were noted in both patient groups when compared to comparisons. Pigeon breeders also demonstrated significant increases in arachidonic-acid. The authors conclude from these results that in patients with occupational diseases of the lung there are important alterations in the lipidic composition of the pulmonary surfactant.
Epidemiology; Silica-dusts; Dust-inhalation; Dust-exposure; Respiratory-system-disorders; Pulmonary-function-tests; Pigeon-breeders-disease; Alveolar-cells
DHHS (NIOSH) Publication No. 90-108
Proceedings of the VIIth International Pneumoconioses Conference, August 23-26, 1988, Pittsburgh, Pennsylvania, USA