An early indicator for pulmonary fibrosis in asbestos exposure: the serum level of type iii procollagen peptide.
Cavalleri-A; Gobba-FM; Bacchella-L; Ferrari-D
NIOSH 1990 Sep:414-417
An investigation was conducted to measure serum type-III procollagen peptide (PIIIP) levels in subjects exposed to asbestos (1332214) in order to evaluate the usefulness of the test in the biological monitoring of asbestos exposure. Twenty nine male workers occupationally exposed to asbestos fibers and employed in two factories producing cement asbestos products were examined. Airborne asbestos fiber exposure was evaluated by stationary and/or personal sampling. The mean value of serum PIIIP was 11.6 nanograms/milliliter (ng/ml) in referents and 16.9ng/ml in exposed subjects, a highly significant difference. Neither in cases nor in referents was a significant difference in serum PIIIP levels noted between smokers and nonsmokers or between alcohol drinkers and nondrinkers. When subjects with low and higher exposure were separately considered, again a significant increase of serum PIIIP values was observed in comparison to the referent group. Workers exposed to higher levels of airborne asbestos fibers revealed the highest values of PIIIP in serum.
Epidemiology; Asbestos-workers; Asbestos-dust; Dust-inhalation; Respiratory-system-disorders; Pulmonary-function-tests; Risk-factors; Biological-monitoring; Cement-industry;
DHHS (NIOSH) Publication No. 90-108
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference