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Request for assistance in preventing bladder cancer from exposure to o-toluidine and aniline.
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-116, 1990 Dec; :1-12
NIOSH has warned that workers exposed to o-toluidine (95534) or aniline (62533) may be at increase risk for developing bladder cancer. Studies on the carcinogenic effects of o-toluidine and aniline in humans and animals were reviewed, and information was presented on the number of workers potentially exposed, and on exposure limits. Epidemiological evidence clearly associated exposure to o-toluidine and aniline with an increased risk of bladder cancer. Risk increased with duration of exposure. Effects of o-toluidine and aniline could not be separated in epidemiological studies. Because o-toluidine induced a greater number and variety of tumors in animals at lower doses than aniline, it was more likely to be responsible for the observed bladder cancers. Recommendations were offered for hazard awareness, training, engineering controls, work practices, the use of personal protective equipment, biological monitoring, and medical screening.
Bladder-cancer; Dyeing-industry; Epidemiology; Carcinogenesis; Cancer-rates; Toluidines; Occupational-exposure; Anilines; Industrial-hygiene
Numbered Publication; Alert
NTIS Accession No.
DHHS (NIOSH) Publication No. 90-116
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division