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Lung disease in Chinese textile workers.
Christiani-DC; Wegman-DH; Ye-T; Lu-P
Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 1990 Nov; :1-31
Studies were conducted to determine the 5 year incidence and remission of byssinosis and nonspecific respiratory symptoms of cotton textile workers; to determine the rate of annual decline in pulmonary function; to explore the relative contributions of cotton dust and airborne gram negative endotoxin exposure in development and progression of respiratory symptoms and pulmonary function change; and to explore the persistence of cross shift drops in forced expiratory volume in 1 second (FEV1) over a 5 year period and the association of cross shift change in FEV1 at baseline survey and subsequent development of respiratory symptoms and accelerated loss of FEV1. This 5 year longitudinal study involved 447 cotton textile and 465 silk textile workers in Shanghai, China. Cotton textile workers lost FEV1 at a greater rate than silk textile workers. This accelerated loss in cotton workers occurred in both smokers and nonsmokers. A significant effect of cotton dust exposure was noted. A cross shift change in FEV1 at the time of first survey was strongly predictive of subsequent 5 year loss of FEV1. Exposure to endotoxin was stronger than chest tightness in predicting dyspnea among male cotton workers. There was no detectable dose response relationship for dust or endotoxin in predicting 5 year loss in FEV1. The acute responses to cotton dust seem to predict long term lung function loss.
NIOSH-Grant; Pulmonary-system-disorders; Textiles-industry; Textile-workers; Pulmonary-function-tests; Cotton-industry; Cotton-mill-workers
Environmental Sci & Physiology Harvard School of Public Hlth 665 Huntington Ave Boston, MA 02115
Final Grant Report
NTIS Accession No.
Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts
Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division