Menstrual function in nurses exposed to cancer drugs.
Department of Environmental Health/College of Medicine, University of Cincinnati, Cincinnati, Ohio 1990 Feb; :1-30
This study was designed to explore the relationship between low dose occupational exposure to antineoplastic drugs and menstrual irregularity. A national sample of 2028 nurses participated in this study. They responded to a brief questionnaire requesting information on current employment status, antineoplastic drug and other occupational exposures, and use of protective equipment if they were currently handling antineoplastic drugs. Current menstrual cycle information and general health status was also queried. A subsample of 200 nurses filled out menstrual history questionnaires. The responses indicated that in 1986 there was an association between menstrual dysfunction and the current handling of antineoplastic drugs among subjects aged 30 to 46 years. In data pertaining to 1988 there was no statistically significant difference in the prevalence of menstrual dysfunction in exposed versus comparison subjects. The use of protective equipment from 1985 to 1988 was compared. Overall, the use of such equipment has increased. Consistent use of gloves increased from 72.8 to 84.2% when mixing antineoplastics, while consistent use of gowns while mixing only increased from 36.6 to 37.3%. Availability of vertical flow hoods increased from 35 to 65%. Nurses reported an increase in the consistent use of gloves while administering antineoplastics, 53 to 76%, while use of other protective equipment was rare.
NIOSH-Grant; Reproductive-system-disorders; Nursing; Health-care-personnel; Personal-protective-equipment; Antineoplastic-agents; Occupational-exposure; Menstrual-disorders
Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, Ohio 45267
Final Grant Report
NTIS Accession No.
Department of Environmental Health/College of Medicine, University of Cincinnati, Cincinnati, Ohio
University of Cincinnati, Cincinnati, Ohio