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Subchronic inhalation of triethylamine vapor in Fischer-344 rats: organ system toxicity.
Lynch DW; Moorman WJ; Lewis TR; Stober P; Hamlin RD; Schueler RL
Toxicol Ind Health 1990 May; 6(3-4):403-414
An investigation was conducted to more fully investigate the subchronic toxicity of inhaled triethylamine (121448) (TEA) in rats. Effects of inhaled TEA on other selected organ systems, including the heart, were also investigated. Weanling caesarean derived Fischer-344-rats were exposed at 25 or 247 parts per million TEA for 6 hours a day, 5 days a week, for 28 weeks. Animals were sacrificed after 32 to 34, 58 to 61, and 125 to 127 days. Exposed rats demonstrated no statistically significant differences compared to the controls in any of the measured indices including treatment related effects on organ weights, hematology, clinical chemistry, or electrocardiographic indices. No evidence was observed of any cardiac muscle degeneration or any changes in electrocardiograms or related clinical chemistry indices. The authors state that the data obtained from this investigation suggests that inhaled TEA, at the concentrations tested, does not induce cardiotoxicity in rats.
NIOSH-Author; Amines; Laboratory-animals; Cardiovascular-system-disorders; Inhalation-studies; Corrosion-inhibitors; Blood-analysis; Organic-vapors
Issue of Publication
Toxicology and Industrial Health
Page last reviewed: September 11, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division