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Developmental toxicology of industrial alcohols: a summary of 13 alcohols administered by inhalation to rats.
Nelson BK; Brightwell WS; Krieg EF Jr.
Toxicol Ind Health 1990 May; 6(3-4):373-387
Results were summarized from a series of studies investigating the developmental toxicology of aliphatic alcohols administered by inhalation to rats. The study was undertaken to investigate the hypothesis that the developmental toxicity of the alcohols would increase as carbon chain length increased, up to 6 to 8 carbons, after which the developmental toxicity would decrease. Several of the alcohols, including methanol (67561), 1-propanol (71238), isopropanol (67630), and 1-butanol (71363), produced developmental toxicity in rats when administered by inhalation throughout gestation. However, when developmental toxicity was observed, it was at high concentrations, typically greater than ten times the Permissible Exposure Limits, and generally in the presence of maternal toxicity. Selective developmental toxicity was not apparent. The authors concluded that developmental toxicity would not be induced in rats by inhalation of the alcohol vapors investigated at the concentrations presently permitted in the workplace. There were no effect concentrations determined for 2- butanol (78922) (adult), isopropanol (fetus), 2-butanol (adult), tert-butanol (75650) (adult and fetus), 1-pentanol (71410) (adult), and 2-ethyl-1-hexanol (104767) (adult). The reproductive toxicity to male rats of high concentrations of 1-propanol should be investigated in further studies.
NIOSH-Author; Reproductive-effects; Developmental-disorders; Embryotoxicity; Chemical-structure; Reproductive-system-disorders; Embryopathology; Aliphatic-compounds; Laboratory-animals; Inhalation-studies
67-56-1; 71-23-8; 67-63-0; 71-36-3; 78-92-2; 75-65-0; 71-41-0; 104-76-7
Issue of Publication
Toxicology and Industrial Health
Page last reviewed: September 11, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division