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NIOSH Testimony on Occupational Exposure to 1,3-Butadiene by J. D. Millar, November 9, 1990.
NIOSH 1990 Nov:23 pages
This testimony concerns the views of NIOSH regarding the proposed rule for worker exposure to 1,3-butadiene (106990) (BD) which is a potential occupational carcinogen, developmental toxicant, and possible reproductive hazard. The present permissible exposure limit of 1000 parts per million (ppm) is seen as inadequate and the new proposed rule would lower this to 2ppm. NIOSH also reviews the toxicity data used by OSHA in establishing its concern over carcinogenicity and reproductive effects. Epidemiologic studies have revealed excesses in mortality from lymphatic and hematopoietic neoplasms. The major concern that NIOSH expresses regarding OSHA's risk assessment model is the choice of tumor response which was modeled. OSHA's rationale for using this particular tumor response was that it occurs so rarely naturally, that its occurrence has to be a result of BD exposure. Other items discussed in the testimony include the feasibility of controlling exposure, medical surveillance, respiratory protection, protective clothing and equipment, and sampling and analytical methods.
NIOSH-Author; NIOSH-Testimony; Millar-J-D; Reproductive-system-disorders; Dienes; Synthetic-rubber-manufacturing; Blood-cells; Leukemogenesis;
NTIS Accession No.
Fertility and Pregnancy Abnormalities; Disease and Injury; Reproductive-system-disorders;
NIOSH, 23 pages, 33 references
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division