Mortality among U.S. workers employed in the production of chemicals contaminated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD).
Fingerhut-MA; Halperin-WE; Marlow-DA; Piacitelli-LA; Honchar-PA; Sweeney-MH; Greife-AL; Dill-PA; Steenland-K; Suruda-AJ
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, 1990 Dec; :1-40
A retrospective cohort mortality study was conducted in a cohort of 5,172 chemical workers from 12 facilities located in the United States. Workers had histories of exposure to phenoxy herbicides and chlorophenols contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (1746016) (TCDD). A review of process descriptions and job duties was used along with measurement of serum TCDD levels to document occupational exposure. In this cohort the mortality from several rare cancers previously associated with TCDD contamination was not notable. In a subcohort of 1,520 workers with more than one year of exposure and more than 20 years of latency, soft tissue sarcoma (STS) mortality was significantly elevated (standard mortality ratio (SMR) 922). Respiratory system cancer was also significantly elevated (SMR 142) in this subcohort. Mortality due to all cancers combined was significantly elevated both in the cohort (SMR 115) and the subcohort (SMR 146). Mortality due to all accidents was also significantly elevated in the cohort (SMR 128). The authors conclude that the excess cancer mortality, especially in the subcohort, is consistent with TCDD being a carcinogen.
NIOSH-Author; Mortality-data; Mortality-surveys; Cancer-rates; Epidemiology; Occupational-exposure; Pesticides; Dioxins; Chemical-industry-workers; Chlorinated-phenols
NTIS Accession No.
National Institute for Occupational Safety and Health