In 1984, cardiovascular diseases accounted for almost a million deaths, the majority from ischemic or coronary heart disease. Major contributors to risk of this disease include cigarette smoking, dietary intake, and hypertension. Other factors include excessive alcohol intake, obesity, diabetes, inadequate physical activity and behavior pattern. The workplace can have a deleterious effect on cardiovascular health. Factors at the workplace which contribute to heart disease include exposures to chemical and physical agents as well as work related psychosocial factors. The proposed strategy is based on reducing cardiotoxic exposures in the workplace, enhancing health behaviors through worksite health promotion, and conducting additional research on the association of work related psychosocial factors and cardiovascular disease.