This document presents a proposed national strategy for the prevention of dermatological conditions resulting from workplace exposures that directly and adversely affect the structure and/or function of the skin. These conditions include both acute injuries and chronic diseases. The skin may be not only the target organ, but can also be the port of entry for toxic chemicals to the body. A preliminary assessment and characterization of the various dermatological conditions that may afflict workers is essential before rational strategies can be formulated to prevent and control these disorders. The report discusses important causal agents, risk factors, and clinical outcomes towards which effective strategies can be directed. Conditions specifically discussed include contact dermatitis, both irritant and allergic, and injuries to the skin such as cuts, lacerations, punctures, and abrasions. Additional topics include personal protection, hygiene, health care delivery, human resources, and economic and material resources. Implementation of prevention strategies includes education and training of workers and management, dissemination of information on health hazards and safe work practices, corporate employment policies and practices, motivation of workers and management to maintain safe and healthy work environments, and regulation of workplace exposures.