Overview of reproductive and developmental toxicity studies of 1,3-butadiene in rodents.
Morrissey-RE; Schwetz-BA; Hackett-PL; Sikov-MR; Hardin-BD; McClanahan-BJ; Decker-JR; Mast-TJ
Environ Health Perspect 1990 Jun; 86:79-84
The results of four 1,3-butadiene (106990) (BD) toxicity investigations were presented. Pregnant Sprague-Dawley-rats and Swiss-(CD-1)-mice were exposed to atmospheric concentrations of 40, 200, or 1000 parts per million (ppm) BD for 6 hours a day on days 6 through 15 of gestation and sacrificed on day 18 (mice) or day 20 (rats). Other tests were performed on B6C3F1-mice and Swiss-(CD-1)- mice exposed to atmospheric concentrations of 200, 1000, or 5000ppm BD for 6 hours a day for 5 consecutive days. No developmental toxicity was observed in rats at any of the concentrations tested, even in the presence of maternal toxicity at 1000ppm. These investigations revealed developmental toxicity in mice in the presence of maternal toxicity (200 and 1000ppm BD) and decreased fetal body weight in the absence of maternal toxicity (40ppm). Sperm head morphology and dominant lethal assays in mice given concentrations of BD between 200 and 5000ppm indicated responses that may be indicative of weak germ cell mutagenic activity. The possibility of germ cell effects was supported by clear evidence of genotoxicity in somatic cells, as indicated by significant increases in sister chromatid exchange at a concentration of 6ppm BD, as well as by other genotoxicity assays.
NIOSH-Publication; NIOSH-Author; Genotoxic-effects; Laboratory-animals; Carcinogens; In-vivo-study; Dose-response; Butadienes; Inhalation-studies; Reproductive-effects; Comparative-toxicology
Environmental Health Perspectives