NIOH and NIOSH basis for an occupational health standard: di(2- ethylhexyl)phthalate (DEHP).
Garberg-P; Hogberg-J; Lundberg-I; Lundberg-P
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 90-110, 1990 Jan; :1-53
Health effects of exposure to di(2-ethylhexyl)phthalate (117817) (DEHP) were reviewed. Topics included: physical and chemical properties; occupational exposure to DEHP; kinetics and metabolism; acute toxicity; biochemical effects; skin and eye irritation; chronic toxicity; reproductive, embryotoxic and teratogenic effects; mutagenicity and genotoxicity; carcinogenicity; and effects on man. Time weighted average exposures in a phthalate manufacturing facility were 0.02 to 4.1mg/m3 for six heavily exposed workers. No accumulation has been observed. DEHP was found to have low acute toxicity. Long term exposures to rats has caused testicular atrophy. DEHP was carcinogenic and teratogenic in tests in rodents. Most genotoxicity tests have been negative. However, certain tests have indicated that DEHP may affect the genome in-vitro.
Phthalates; Plastics-industry; Laboratory-animals; Reproductive-hazards; Toxic-effects; Carcinogens; Teratogens; Genotoxic-effects
Numbered Publication; Criteria Document
NTIS Accession No.
DHHS (NIOSH) Publication No. 90-110
National Institute for Occupational Safety and Health