Screening workers exposed to 4,4'-methylenebis(2-chloroaniline) for bladder cancer by cystoscopy.
Ward-E; Halperin-W; Thun-M; Grossman-HB; Fink-B; Koss-L; Osorio-AM; Schulte-P
J Occup Med 1990 Sep; 32(9):865-868
An investigation was begun in 1981, by a request from the Michigan Department of Public Health, to examine possible hazardous on the job exposure to methylenebis(2-chloroaniline) (27342752) (MBOCA) among workers at a small chemical facility. The facility had come to the attention of the state department of health 2 years earlier when extensive environmental contamination had been discovered in the community surrounding the site. A bladder cancer incidence study was conducted among 540 workers exposed to MBOCA from 1969 to 1979. None of the 385 workers who participated in a urine screening examination had suspicious or positive cytology. At least one reading of atypia was observed in 21 workers and 60 workers had either a positive dipstick for heme or greater than 5 red blood cells per low power field. The diagnosis by cystoscopy of a bladder tumor in a nonsmoking man less than 30 years of age with low level hematuria prompted the research team to offer cytoscopy to all members of the cohort. A total of three tumors were identified in 200 persons who received cystoscopy. All were low grade, papillary tumors. Two occurred in men with completely normal urine screening results. These results suggest that cystoscopy of asymptomatic persons should be considered in designing bladder cancer screening programs in high risk cohorts.
JOCMA7; NIOSH-Author; Medical-screening; Screening-methods; Cancer-rates; Worker-health; Occupational-health-programs; Industrial-health-programs; Chemical-industry-workers
Journal of Occupational Medicine