Serum oncogene proteins in foundry workers.
Brandt-Rauf-PW; Smith-S; Perera-FP; Niman-HL; Yohannan-W; Hemminki-K; Santella-RM
J Soc Occup Med 1990 Jan; 40(1):11-14
An inquiry into the carcinogenic predictive value of serum oncogene proteins was conducted for an occupational cohort with known exposure to benzo(a)pyrene (50328) and other polycyclic aromatic hydrocarbons (PAHs). The cohort consisted of a group of iron foundry workers in Finland whose occupational histories and exposures were well defined. Ten unexposed workers were examined as referents. The exposed individuals were divided into subgroups based on benzo(a)pyrene exposure levels which were known from sampling data. Blood samples were obtained from all workers and analyzed for PAH-DNA adducts and protein products encoded by nine specific oncogenes. Overall, four samples were demonstrated to be positive for a specific oncogene protein product. The samples were repeat measurements from two of the foundry workers. None of the referent group exhibited any of the protein products which may correlate with carcinogenesis. The cases in which oncogene encoded protein products were identified came from one individual with high exposure and another with a medium level of exposure. It was noted that workers in the medium and high exposure groups had significantly higher PAH-DNA adduct levels when compared to workers with low exposure or referents. The authors speculate that the two workers who tested positive for oncogene protein products and had high levels of PAH-DNA adducts have a high probability of developing malignant disease. However, they also state that these results must be interpreted cautiously since more study is required. Finally, the authors conclude that oncogene proteins and DNA adducts are possible epidemiological markers for exposed worker populations.
NIOSH-Publication; NIOSH-Grant; Blood-serum; Oncogenesis; Occupational-exposure; Iron-workers; Polycyclic-aromatic-hydrocarbons; Protein-biochemistry; DNA-adducts
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
Journal of the Society of Occupational Medicine
Columbia University New York, New York, New York