Half-life of polychlorinated biphenyls in occupationally exposed workers.
Phillips DL; Smith AB; Burse VW; Steele GK; Needham LL; Hannon WH
Arch Environ Health 1989 Nov; 44(6):351-354
The changes in polychlorinated-biphenyl (1336363) (PCB) concentrations in humans were followed over an 8 year period in occupationally exposed workers. The group of 228 workers at an electrical equipment manufacturing plant in Bloomington, Indiana was first studied in 1977. Aroclor-1242 (53469219) was used at this site in the production of capacitors from 1959 through 1971. Aroclor-1016 (12674112) was used from 1971 through 1977. PCBs were being phased out of operation at this site in 1977. In August of 1985, 60 of the same workers were examined again. At the time of the second examination, the workers were 32 to 67 years old. Blood samples were collected and analyzed for PCBs. There was a decrease in PCB levels over time. The median half life was 2.5 years for Aroclor-1242 and 4.8 years for Aroclor-1254. However, an inverse relationship was noted between the half life values and initial serum concentrations. The authors suggest that this pattern may be a result of continued low level exposure, variation in the time of exposure, or enzyme induction by PCBs.
NIOSH-Author; Chlorinated-hydrocarbons; Electrical-industry; Polycyclic-aromatic-hydrocarbons; Metabolic-study; Blood-analysis; Industrial-factory-workers; Occupational-exposure
1336-36-3; 53469-21-9; 12674-11-2
Archives of Environmental Health