Oncogene proteins as molecular epidemiologic markers of cancer risk in hazardous waste workers.
Occup Med: State of the Art Rev 1990 Jan; 5(1):59-65
Using oncogene proteins as molecular epidemiologic markers of cancer risk for hazardous waste site workers was discussed. The role of oncogenes and oncogenesis in carcinogenesis was summarized. The oncogene theory of carcinogenesis was based on the observation that protooncogenes, preexisting normally innocuous cellular DNA sequences, can be altered during oncogenesis to produce oncogenes that have the ability to induce malignant transformation of cells. Activated oncogenes were postulated to exert their transforming effect on cells by expressing encoded protein products (oncogene products). Carcinogens such as benzo(a)pyrene (50328), N-nitroso compounds, and 7,12-dimethylbenz(a)anthracene (57976) have been shown to cause oncogene activation. Renal, gynecological, gastrointestinal, lung, and breast tumors and leukemias, lymphomas, and sarcomas have shown high levels of oncogene expression. The ras oncogene and its relationship to carcinogenesis were discussed. Several studies have shown that activation of the ras oncogene by point mutation is a common event in human tumorigenesis. The ras oncogene has also been detected in premalignant lesions. Animal studies have also demonstrated that spontaneous and chemically induced tumors contain the ras oncogene. These findings have suggested that ras oncogenes could be a marker for the early stage of malignancy. Immunologically based serum screening assays for ras and other oncogenes in cancer patients and municipal workers engaged in hazardous waste cleanup have indicated that oncogene protein determinations could be a useful tool for the early detection and prevention of cancer in hazardous waste workers and other groups potentially exposed to carcinogens.
NIOSH-Publication; NIOSH-Grant; Genetic-factors; Molecular-biology; Hazardous-waste-cleanup; Risk-analysis; Carcinogenicity; Biological-monitoring; Waste-disposal; In-vivo-studies; Genotoxic-effects
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
Gochfeld M; Favata EA
Occupational Medicine: State of the Art Reviews. Hazardous Waste Workers
Columbia University New York, New York, New York