Serum oncogene proteins in hazardous-waste workers.
Brandt-Rauf-PW; Smith-S; Niman-HL; Goldstein-MD; Favata-E
J Soc Occup Med 1989 Jan; 39(4):141-143
A study of serum oncogene proteins in hazardous waste workers was conducted. The study group consisted of 17 males, average age 40 years, who were involved in cleanup operations at a variety of hazardous waste sites. The average extent of cigarette smoking was 7.5 pack years. Blood samples were collected and analyzed for nine oncogene proteins by a serum immunoblotting technique with monoclonal antibodies. The results were compared with those obtained previously in a study of 16 hazardous waste workers with known carcinogen exposures. Only two workers had trace positive bands (less than a two fold increase above background) for the ras oncogene protein. Both subjects were heavy smokers, having 14 and 20 packyears of exposure. In the previous study, 10 workers were positive for at least one serum oncogene protein of type ras, fes, or sis. The authors conclude that the occurrence of only two cases of oncogene activation suggests that the workers have minimized their exposures to hazardous wastes by wearing protective clothing and equipment and observing appropriate work practices. Activation of the ras oncogene in the two workers may be a reflection of their cigarette smoking. The large number of positive findings in the previously studied group may reflect actual exposure to carcinogens.
NIOSH-Publication; NIOSH-Grant; Genetic-factors; Waste-disposal; Bioactivation; Blood-serum; Cigarette-smoking; Risk-factors; Neoplastic-agents; Occupational-exposure; Immunochemistry
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
Journal of the Society of Occupational Medicine
Columbia University New York, New York, New York