NIOSH Testimony on Dioxin by J. D. Millar, November 9, 1983.
NIOSH 1983 Nov:5 pages
This testimony concerned studies conducted by NIOSH related to long term health consequences among workers exposed to dioxin (1746016) contaminated products. The Dioxin Registry and Mortality Study was summarized exploring the relationship between soft tissue sarcoma and dioxin exposure. A cohort of workers was identified through this registry who are known to have worked in chemical processes which generated dioxin. This group constitutes a unique population of persons with documentation of potential exposure to dioxin among whom meaningful epidemiological observations can be made. A extensive review was also made of medical literature concerning the link between exposure to dioxin and soft tissue sarcoma. Several clinical cases of soft tissue sarcoma were observed among Swedish lumberjacks previously exposed to dioxin contaminated products. A study of these individuals indicated that workers exposed to dioxin had a five to six fold greater risk of developing a soft tissue sarcoma than those not exposed. Similar studies were conducted in the United States among workers exposed to the herbicide 2,4,5- trichlorophenoxy-acetic-acid (93765) or its chemical precursor, trichlorophenol (95954). Of the total of seven cases of soft tissue sarcoma identified among United States workers, two were histologically verified. Even these two represent an excess over the less than one case that would have been expected statistically. The results of these studies were not considered to confirm a link between dioxin and soft tissue sarcoma, but they did provide sufficient reason for continuing the study.
NIOSH-Author; NIOSH-Testimony; Millar-J-D; Herbicides; Environmental-contamination; Environmental-pollution; Chlorinated-hydrocarbons; Chemical-manufacturing-industry; Epidemiology; Occupational-exposure;
1746-01-6; 93-76-5; 95-95-4;
NTIS Accession No.
NIOSH, 5 pages