Experimental Pneumoconiosis of Sandblasting Substitutes.
Hammad-YY; Abdel-Kader-H; Bozelka-B; Hughes-J; Weill-H
School of Medicine, Tulane University, New Orleans, Louisiana 1989 Sep:29 pages
A study was conducted to evaluate the pulmonary fibrogenic potential of STANBLAST. This substance is a sand substitute extensively used in the State of Louisiana. The study was conducted using both normal and silicotic rats. Analysis indicated that STANBLAST was a complex silicate with trace amounts of several elements. STANBLAST granules were milled in a ball mill to produced dust for animal exposures. Male rats were exposed by inhalation in a horizontal laminar flow whole body exposure chamber to 10.8 milligrams of the STANBLAST dust/cubic meter, 6 hours a day, 5 days a week for 1 year. Rats were killed 6 to 24 months after the start of exposure, and lungs were examined. Histologic examinations of the exposed lungs revealed the presence of microgranulomas throughout the lung fields, suggesting the release of certain cellular modifying agents. The absence of any obvious collagen deposition within the structures of the surrounding interstitium indicated a lack of fibrogenic potential for STANBLAST under the conditions of this experiment. The lack of significant difference in hydroxyproline content of the lungs of exposed and control rats corroborated the histologic conclusions.
NIOSH-Grant; Pulmonary-system-disorders; Laboratory-animals; Construction-workers; Construction-materials; Lung-disease; Silicates;
Medicine Tulane University 1700 Perdido Street New Orleans, LA 70112
Final Grant Report;
NTIS Accession No.
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
School of Medicine, Tulane University, New Orleans, Louisiana
Tulane University of Louisiana, New Orleans, Louisiana