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A Retrospective Study of Inferred Fertility of Married Men Occupationally Exposed to Ethylene Dibromide (EDB). Final Report.

Equitable Environmental Health, Inc, Rockville, Maryland, 1977 Nov:20 pages
A retrospective study of reproductive effects of exposure to ethylene-dibromide (106934) (EDB) in a group of exposed male workers was conducted. Reproductive histories of the wives of EDB exposed workers were examined. Data on the date of birth of each wife, the date of birth of the worker husband, race, dates of birth of all live born natural children, details on adopted children and children by previous marriages of wives, dates of marriages, and other pertinent factors were collected for workers at four firms in the United States. Less complete data was also obtained from one facility in the United Kingdom. A negative result was obtained for all facilities studies except the Houston facility cohort. Examining high and low exposure categories gave no consistent evidence of any dose response relationship. In the Houston cohort, the observed/expected births ratio was consistently and significantly low, suggesting a possible antifertility effect. Relative exposure categories were not available, so any dose response relationship which might exist could not be found. The prevalence of vasectomy among the EDB workers at this site was particularly high. Other cases of sterility of either husband or wife from preexisting causes gave a total of 22/67 couples or 33 percent of the study group at this site who did not offer a valid test of the potential antifertility effect of exposure to EDB. It appeared that a negative finding was also the outcome of the British study.
NIOSH-Contract; Chemical-industry-workers; Chemical-manufacturing-industry; Halogenated-hydrocarbons; Reproductive-system-disorders; Spermatogenesis; Laboratory-animals; Spermatozoa; Fumigants; Reproductive-hazards;
Publication Date
Document Type
Final Contract Report;
Fiscal Year
NTIS Accession No.
NTIS Price
Priority Area
Fertility and Pregnancy Abnormalities; Disease and Injury; Reproductive-system-disorders;
Source Name
Equitable Environmental Health, Inc, Rockville, Maryland, 20 pages
Page last reviewed: September 4, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division