Comparative cocarcinogenic effects of crocidolite asbestos, hematite, kaolin and carbon in implanted tracheal organ cultures.
Ann Occup Hyg, Inhaled Particles V, 1982 Sep; 26(1-4):553-567
The cocarcinogenic effects of a fibrous crocidolite (12001284) asbestos and three nonfibrous minerals, hematite (1317608), kaolin (1332587), and carbon (1333864), were assessed after coating the particulates with the polycyclic aromatic hydrocarbon 3- methylcholanthrene (56495) (3MC). Tracheal organ cultures from golden-Syrian-hamsters exposed to the carcinogen treated dusts in- vitro were implanted subsequently into syngeneic animals. The affinity of the particle for the hydrocarbon and uptake of the 3MC by the tracheal epithelium were examined to determine the influence of these factors in carcinogenesis of the respiratory tract. Tumors, primarily carcinomas, appeared after exposure of organ cultures to 3MC coated particles, but not after exposure to the particles themselves. Considering the total number of tumors, the relative cocarcinogenicity of the dusts was crocidolite asbestos, followed by hematite, kaolin, and finally carbon, the least potent in this study. Relatively few carcinomas were found in animals exposed to carbon coated with 3MC. No relationship was noted between carcinogenicity and the affinity of the particle for 3MC or the elution of the hydrocarbon from the dust. The authors suggest that factors other than particle enhanced availability of PAH were important in carcinogenesis in the respiratory tract.
NIOSH-Publication; NIOSH-Grant; Control-technology; Pulmonary-system-disorders; Asbestos-fibers; Carcinogens; Airborne-fibers; Mineral-dusts; Laboratory-animals; In-vitro-studies; In-vivo-studies
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Annals of Occupational Hygiene, Inhaled Particles V
University of Vermont & St Agric College, Burlington, Vermont