This statement reviewed the role of NIOSH in investigating ethylene- dichloride (107062) (EDC) and 2,4-diaminoanisole (615054) (DA). Occupational exposure to the chemical intermediate EDC was minimal. In 1976 a criteria documents suggested the standard for exposure to EDC be set at 5 parts per million (ppm) based on reports of adverse effects on the nervous system and livers of workers exposed to 10 to 15ppm EDC. Higher exposure levels were apparently related to cardiac and respiratory system effects. Nursing mothers were advised not to work with EDC as it could be carried in their milk. Subsequent to this time reports were made of excessive tumors occurring in laboratory mice and rats fed EDC for 78 weeks. If these reports are proved accurate, further recommendations will be made concerning exposures to EDC. In January of 1978 NIOSH issues a Current Intelligence Bulletin recommending that DA and its salts be handled as though they were human carcinogens. Two epidemiologic studies have been reported where excessive cancer has been diagnosed among cosmetologists. One study suggested excessive genital cancer and the other suggested excessive cancer in several organ systems. Other reports indicated mutagenic potential in bacterial systems and in the fruit fly. NIOSH recommended that skin exposure be limited and that engineering and work practice controls be made more stringent.
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