Vanadium toxicity: a study of mechanisms.
Report 1973 Feb; :1-3
The purpose of the investigation was to produce marginal chromium (7440473) deficiencies in rats through manipulation of their diets. After this deficiency was produced, small amounts of vanadium (7440622) compounds were added to the drinking water of the animals and the effects of this addition were studied. One group of rats were fed a diet deficient in chromium with 5 micrograms of chromium/milliliter drinking water. No increase was noted in the glucose metabolism on this diet. A second group received 10 micrograms chromium/milliliter drinking water. No differences were noted between the group supplemented with chromium and the control group, or the group supplemented with vanadium at 5 micrograms vanadium/milliliter water and the control group or the groups supplemented with chromium and vanadium, concerning measurements of cholesterol in plasma. The findings were at variance with other published reports and indicated that only under certain circumstances did exposure to vanadium and chromium cause changes in the metabolism of cholesterol. The author suggests that this experimental approach is probably not appropriate for the study of vanadium intoxication in industrial settings. However, this approach may be useful in studies on the pathogenesis of atherosclerotic heart disease.
NIOSH-Grant; Grants-other; Vanadium-compounds; Metabolic-study; Cardiovascular-system-disorders; Dietary-effects; Laboratory-animals
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
Final Grant Report
NTIS Accession No.
University of Cincinnati, Cincinnati, Ohio