Analysis of Neurotoxic Disease: The Acrylamide Experience.
Recent Advances in Nervous System Toxicology 1988:163-176
The orderly analysis of neurotoxic disease was discussed, based on experience with a number of human neurotoxins, notably the industrial monomer acrylamide (79061). The method for investigating a human neurotoxic disorder initially requires the human syndrome to be defined in detail. Next the researcher must develop a valid animal model which reproduces as many features of the human disorder as possible. Following the development of the model, the spatial temporal sequence of pathophysiological events may be established. Once the initial pathological change is identified, clues to the nature of the disorder may be provided. From this point biochemical studies are designed to address basic mechanisms. This information will also allow the development of methods to detect the early stages of the disease in humans. Identification of disease mechanisms will often reveal methods to circumvent the disorder. These methods may prove valuable in the design of drugs to prevent or ameliorate the human disease. In the case of acrylamide, the entire process has taken 30 years thus far and is not as yet completed.
NIOSH-Grant; Neurotoxic-effects; Acrylamides; Nervous-system-disorders; Analytical-models; Neurotoxicity; Diagnostic-techniques; Clinical-pathology; Laboratory-animals;
Neuroscience Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, New York 10461
Galli-CL; Manzo-L; Spencer-PS;
Neurotoxic Disorders; Neurotoxic-effects;
Recent Advances in Nervous System Toxicology
Yeshiva University, New York, New York