Hypercholesterolemia in rats produced by an increase in the ratio of zinc to copper ingested.
Am J Clin Nutr 1973 Oct; 26(10):1060-1068
Efforts were made to determine whether an alteration in the amount of metallic elements ingested by rats would produce a change in the concentration of cholesterol in the plasma of the animals. Rats were fed a purified diet and the amount of zinc (7440666) and copper (7440508) taken was regulated through the drinking water. The study progressed over a 3 year period in two different environments. Drinking water with a ratio of zinc to copper of 40 consistently and significantly produced higher concentrations of cholesterol in the plasma than did water with a ratio of 5. This increased ratio of zinc to copper caused an increase in the concentration of cholesterol in plasma and presumably resulted in increased risk of coronary heart disease. Such an increased risk may add to genetic, dietary and other factors that influence the atherogenic processes.
NIOSH-Publication; NIOSH-Grant; Grants-other; Laboratory-animals; Dietary-effects; Metallic-salts; Cardiovascular-system-disorders; Nutrition
Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
Other Occupational Concerns; Grants-other
The American Journal of Clinical Nutrition
University of Cincinnati, Cincinnati, Ohio