Susceptibility to cold in newborns of levodopa-treated rats.
Mena I; Lopez G; Horiuchi K; Croxatto H Jr.
Nature 1972 Sep; 239(5370):285-287
The effect on cold susceptibility of the offspring of rats treated with levodopa was examined. Studies were made of the offspring of Sprague-Dawley rats treated with levodopa before mating or during gestation. Control animals were treated with saline. A blue spot, which appeared a few hours after birth, between the scapulae of some newborn rats, occurred with a much higher incidence rate in the offspring of treated mothers, even among those treated only during the first five days of gestation. No effect was noted from levodopa treatment during the two weeks prior to mating. Levodopa also increased the spontaneous mortality rate. Dissection revealed extensive subcapsular hemorrhages restricted specifically to the brown fat. Hemorrhages did not occur during intrauterine life. Exposure of the offspring to 10 degrees-C until death indicated that survival was reduced markedly in blue spot animals and to a lesser extent in the rest of the offspring of the treated mothers in comparison with those treated with saline. The authors suggest the blue spot is a manifestation of an extreme form of some lesion in brown fat, promoted by levodopa. The incidence of hemorrhage in the brown fat was greatly reduced by the addition of manganous chloride to the regimen. The effect of manganese administration could be due to some change in the metabolism of levodopa. Administration of a manganese deficient diet of cow milk with levodopa markedly increased both incidence of bluespot and mortality of newborns.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Pharmaceuticals; Medical-treatment; Cold-tolerance; Reproductive-effects; Laboratory-animals; Prenatal-exposure; Central-nervous-system
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