Effect of cortisol infusions on endogenous cortisol secretion in man.
Perlow M; Weitzman ED; Hellman L
J Clin Endocrinol Metab 1974 Oct; 39(4):790-795
The effect of a series of intravenous cortisol infusions on the subsequent 24 hour pattern of cortisol secretion was observed in a normal young adult male. The subject was acclimated to the sleep research laboratory one night preceding each of three 48 hour experimental periods. In one experiment, no acclimatization was carried out. For seven of the eight experimental nights, the sleep stage patterns and percentage of the night sleep period were normal. One night was disturbed by a malfunctioning of the sampling catheter. A consistent pattern in cortisol concentration was apparent from day to day with a remarkable degree of coincidence for both the timing and magnitude of the secretory episodes. Intravenous infusions of 17 to 20 milligrams of cortisol for the 4.5 to 6.5 hour periods at different times of the day elevated the plasma cortisol concentrations to sustained high levels, but were still within the normal physiological range. Following cessation of the infusion, the plasma cortisol concentrations fell at a constant rate for 4.5 to 5.5 hours. No correlation was noted between either the mean cortisol concentration achieved during the infusion periods or the time of day during which the infusions were given and the duration of the periods from the end of the infusion to the onset of endogenous cortisol secretion. On the day of infusion there was a 78, 46, and 13 percent increase in urinary 17-hydroxycorticosteroid, 17-ketogenic steroid, and 17-ketosteroid excretions, respectively.
NIOSH-Publication; NIOSH-Grant; Grants-other; Urinalysis; Sleep-deprivation; Circadian-rhythms; Metabolic-study; Hormone-activity; Humans
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
Journal of Clinical Endocrinology and Metabolism
Montefiore Hospital and Medical Center, New York, New York