Liver disease associated with exposure to 1,1,1-trichloroethane.
Hodgson-MJ; Heyl-AE; Thiel-DH
Arch Intern Med 1989 Aug; 149(8):1793-1798
Cases of fatty liver disease (FLD) associated with occupational exposure to 1,1,1-trichloroethane (71556) (TCE) were described. Four males, 28, 27, 45, and 50 years old, who had complained of nausea, anorexia, chills, and fatigue were examined at an occupational medical clinic. All were diagnosed with FLD on the basis of a liver biopsy. The 45 year old patient had evidence of inactive cirrhosis. The 50 year old subject had active cirrhosis. None of the patients had any predisposing FLD factors such as excessive alcohol use, a history of receiving blood or blood products, or serological evidence of previous hepatitis-B or other viral infections. One patient denied any alcohol consumption. All four subjects had been occupational exposed to TCE. Estimated TCE exposures ranged up to 17718 parts per million. Two subjects reported minimal exposures to perchloroethylene (127184). The authors conclude that although the cases do not definitely establish a causal association they do raise the question of whether FLD can be associated with exposure to TCE. Since TCE has been shown to produce liver disease in laboratory animals and is associated with some degree of liver dysfunction in humans after substantial exposure and has not been shown to be safe, it should be regarded as potentially hepatotoxic to humans.
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Organo-chlorine-compounds; Organic-solvents; Occupational-exposure; Case-studies; Liver-disorders; Clinical-symptoms; Toxic-effects
Medicine University of Pittsburgh 149 Lothrop Hall Pittsburgh, PA 15261
Archives of Internal Medicine
University of Pittsburgh at Pittsburgh, Pittsburgh, Pennsylvania