Preventing occupational skin diseases through using chemical protective gloves was discussed. The technique for selecting chemical protective gloves was summarized. This involves performing job task and chemical exposure analyses which reveal the physical and chemical properties needed for resisting attack by the expected chemical exposures. The properties of elastic polymers or elastomers used in chemical protective gloves were summarized. It was noted that in selecting a protective glove its physical properties, which depend on glove thickness and surface texture, must be balanced against the chemical resistance requirements such at its ability to resist degradation and permeation. Evaluating degradation and permeation were considered. Practical applications of data on degradation and permeation when testing candidate gloves were discussed. Procedures for selecting chemical protective gloves were illustrated using three case studies. They involved a worker who developed irritant contact dermatitis after spray painting small automobile parts, a gas company employee who developed allergic contact dermatitis resulting from exposure to the diglycidyl ether of bisphenol-A used as a binder in epoxy resins used to join plastic gas lines, and a worker in a plating facility who was fatally poisoned as a result of immersing his unprotected hands in a sodium- cyanide (143339) plating solution.