Arsine: toxicity data from acute and short-term inhalation exposures.
Fowler-BA; Moorman-MP; Adkins-B Jr.; Bakewell-WE Jr.; Blair-PC; Thompson-MB
Hazard assessment and control technology in semiconductor manufacturing. Chelsea, MI: Lewis Publishers, Inc., 1989 Jan; :85-89
This report presents a brief overview of acute and prolonged exposure studies conducted for arsine (7784421). Male and female Fisher-F344-rats and female B6C3F1-mice were exposed via inhalation to arsine gas at 10 parts per billion to 50 parts per million (ppm) for 6 hours a day for 14 consecutive days, or 5 days a week for 4 or 13 weeks. A 100 percent mortality was experienced within 4 days for all groups exposed to arsine at concentrations above 100ppm. Those exposed to 5ppm or less showed no mortality or overt signs of toxicity. Dose repeated increases were noted in the weight of spleens of dosed animals while the livers showed slight increases in weights following exposure. The spleens showed evidence of red blood cell sequestration in the red pulp, hemosiderin accumulation within the macrophages, and increased erythropoiesis. A slight dose related decrease was noted in packed blood cell volume and a marked dose related increase in the activity of red blood cell delta- aminolevulinic-acid-dehydratase. Immature red cells, reticulocytes, and the presence of Howell-Jolly bodies were noted in the peripheral blood. Greatly elevated concentrations of 7-COOH and 8-COOH uroporphyrins were noted in the urine samples and a more modest increase in 4-COOH coproporphyrins at the 5ppm exposure level. The female rats were a little less sensitive than male rats to the arsine over the 14 day study period. The authors indicate that differential analysis of peripheral blood from arsine exposed workers is necessary to determine whether a compensatory response to this agent is occurring. Measurement of packed cell volume is not sufficient for monitoring the effects from prolonged, low dose arsine exposure.
Urinalysis; Laboratory-animals; Arsenic-compounds; Toxic-gases; Semiconductors; Electronics-industry; Inhalation-studies; Metabolic-study; Blood-analysis
Hazard assessment and control technology in semiconductor manufacturing