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Behavioral teratology investigation of l-propanol administered by inhalation to rats.
Nelson-BK; Brightwell-WS; Taylor-BJ; Khan-A; Burg-JR; Krieg-EF Jr.; Massari-VJ
Neurotoxicol Teratol 1989 Apr; 11(2):153-159
Offspring of female Sprague-Dawley-rats exposed to 7000 or 3500 parts per million 1-propanol (71238) for 7 hours a day throughout gestation, and groups of males exposed to 1-propanol and subsequently mated to nonexposed females were examined for behavioral teratology. Pups were fostered to untreated dams. Behavioral tests included ascent on a wire mesh screen, rotorod, open field activity, optical digital activity monitoring, running wheel, avoidance conditioning, and progressive fixed ratio schedule of reinforcement. Brains from ten rats per group were dissected and assayed for protein, acetylcholine, dopamine, norepinephrine, serotonin, beta-endorphin, Met-enkephalin, and substance-P. The results indicated that exposure to high concentrations of 1-propanol affected fertility in exposed males, but no consistent effects were noted in the behavioral or neurochemical tests measured. This lack of effect was surprising based on predictions from the structural similarity of 1-propanol to ethanol and on long standing observations that toxicity increases with carbon chain length among the aliphatic alcohols. The authors conclude that it is unlikely that exposure to 1-propanol at work will produce functional effects at levels lower than those required to produce malformations. At these levels of exposure 1-propanol is not a selective developmental toxicant, and exposure to concentrations of 1-propanol as carried out in this research will likely not result in behavioral teratogenicity.
Teratogens; Laboratory-animals; Inhalation-studies; Behavioral-testing; Task-performance; Solvents; Alcohols; Transplacental-exposure
Issue of Publication
Neurotoxicology and Teratology
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