Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-614, Second Draft 1981 Nov; :1-109
Information profiles were prepared for the following aminoazobenzenes deemed to be of significance due to the fact that they each had an annual production volume in the range of at least the thousands of pounds: 4-aminoazobenzene (60093), 4- aminoazobenzene-3,4'-disulfonic-acid (101508), 4-aminoazobenzene- 3,4'-disulfonic-acid-disodium-salt (2706287), 4-aminoazobenzene- hydrochloride (3457985), 4'-aminoazobenzene-4-sulfonic-acid (104234), 4'-aminoazobenzene-4-sulfonic-acid-sodium-salt (2491716), ortho-aminoazotoluene (97563), ortho-aminoazotoluene-hydrochloride (2298137), C-I-Disperse-Orange-3 (730405), C-I-Disperse-Red-1 (2872528), C-I-Disperse-Red-5 (3769571), C-I-Disperse-Red-17 (3179893), C-I-Disperse-Yellow-3 (2832408), chrysoidine (532821), 2,4-diaminoazobenzene (495545), and N,N,-diethylaminoazobenzene (2481949). Information suggested that these compounds were only mildly toxic following acute exposure. Organ damage was noted in the liver, kidneys, and spleen following subchronic or chronic exposure to N,N-diethylaminoazobenzene, 4-aminoazobenzene, and ortho- aminoazotoluene. After metabolic activation in the Ames assay, positive findings were obtained for 4-aminoazobenzene, chrysoidine and ortho-aminoazotoluene. Cell transformation assays gave positive results for 4-aminoazobenzene and 4-aminoazobenzene-4-sulfonic-acid. Aminoazobenzenes, 4-aminoazobenzenes, chrysoidine and ortho- aminoazotoluene have tested positively in carcinogenicity studies using laboratory mice. Ortho-aminoazotoluene crossed the placenta and increased tumor incidence in the F1 generation.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-614, Second Draft