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Information Profiles on Potential Occupational Hazards: Thiourea and Compounds.

Anonymous

Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-500, Second Draft 1982 Jan:124 pages

00188280

Information profiles were presented for thiourea and the following thiourea compounds considered important in the industrial community: 1-allyl-3-(2-hydroxyethyl)-2-thiourea (105817), allylthiourea (109579), N,N'-bis(hydroxymethyl)thiourea (3084251), N,N'- bis(methoxymethyl)thiourea (51872265), 1-butyl-3-ethyl-2-thiourea (32900064), 1,3-dibutyl-2-thiourea (109466), 1,3-diisopropyl-2- thiourea (2986176), 1,3-dimethyl-2-thiourea (534134), N,N'-di-o- tolylthiourea (137973), 3-ethyl-1,1-dimethyl-2-thiourea (15361861), ethylthiourea (625536), (hydroxymethyl)thiourea (1000835), (2- methylphenyl)thiourea (614788), thiourea (62566), 1,3-diethyl-2- thiourea (105555), 1,3-diphenyl-2-thiourea (102089), ethylenethiourea (96457), 1-naphthylthiourea (86884), 1-phenyl-2- thiourea (103855), 1,1,3,3-tetramethylthiourea (2782914) and 1,1,3- trimethyl-2-thiourea (2489772). Most of the compounds were highly toxic to rodents. Positive mutagenic effects have been elicited in various assays with several of these compounds. The use of thiourea, diethylthiourea and tetramethylthiourea as antithyroid drugs indicated these compounds have antithyroidal effects in humans. Frequently observed side effects from the use of these medications have included headache, anxiety, fever, skin rash, and gastrointestinal disturbances.

NIOSH-Contract; Contract-210-79-0030; Corrosion-inhibitors; Bactericides; Rodenticides; Coatings; Flame-retardants; Toxic-effects; Mutagens;

105-81-7; 109-57-9; 3084-25-1; 51872-26-5; 32900-06-4; 109-46-6; 2986-17-6; 534-13-4; 137-97-3; 15361-86-1; 625-53-6; 1000-83-5; 614-78-8; 62-56-6; 105-55-5; 102-08-9; 96-45-7; 86-88-4; 103-85-5; 2782-91-4; 2489-77-2;

19820101

Contract;

1982

PB89-215685

A07

Contract-210-79-0030

Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-500, Second Draft

NY;