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Information profiles on potential occupational hazards: thiourea and compounds.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-500, Second Draft 1982 Jan; :1-124
Information profiles were presented for thiourea and the following thiourea compounds considered important in the industrial community: 1-allyl-3-(2-hydroxyethyl)-2-thiourea (105817), allylthiourea (109579), N,N'-bis(hydroxymethyl)thiourea (3084251), N,N'- bis(methoxymethyl)thiourea (51872265), 1-butyl-3-ethyl-2-thiourea (32900064), 1,3-dibutyl-2-thiourea (109466), 1,3-diisopropyl-2- thiourea (2986176), 1,3-dimethyl-2-thiourea (534134), N,N'-di-o- tolylthiourea (137973), 3-ethyl-1,1-dimethyl-2-thiourea (15361861), ethylthiourea (625536), (hydroxymethyl)thiourea (1000835), (2- methylphenyl)thiourea (614788), thiourea (62566), 1,3-diethyl-2- thiourea (105555), 1,3-diphenyl-2-thiourea (102089), ethylenethiourea (96457), 1-naphthylthiourea (86884), 1-phenyl-2- thiourea (103855), 1,1,3,3-tetramethylthiourea (2782914) and 1,1,3- trimethyl-2-thiourea (2489772). Most of the compounds were highly toxic to rodents. Positive mutagenic effects have been elicited in various assays with several of these compounds. The use of thiourea, diethylthiourea and tetramethylthiourea as antithyroid drugs indicated these compounds have antithyroidal effects in humans. Frequently observed side effects from the use of these medications have included headache, anxiety, fever, skin rash, and gastrointestinal disturbances.
NIOSH-Contract; Contract-210-79-0030; Corrosion-inhibitors; Bactericides; Rodenticides; Coatings; Flame-retardants; Toxic-effects; Mutagens
105-81-7; 109-57-9; 3084-25-1; 51872-26-5; 32900-06-4; 109-46-6; 2986-17-6; 534-13-4; 137-97-3; 15361-86-1; 625-53-6; 1000-83-5; 614-78-8; 62-56-6; 105-55-5; 102-08-9; 96-45-7; 86-88-4; 103-85-5; 2782-91-4; 2489-77-2
Final Contract Report
NTIS Accession No.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-500, Second Draft
Page last reviewed: June 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division