Information Profiles on Potential Occupational Hazards: Nitrophenols.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-536, Second Draft 1981 Apr:75 pages
Information profiles were presented for the following nitrophenols deemed important in the industrial community: 2-nitrophenol (88755), 3-nitrophenol (554847), 4-nitrophenol (100027), 2,4- dinitrophenol (51285), and 2,4,6-trinitrophenol (88891). The mononitrophenols were moderately toxic to animals, causing initial stimulation and subsequent depression of the respiratory and central nervous systems. Positive results were obtained in several mutagenicity assays for 3-nitrophenol and 4-nitrophenol. 2,4- Dinitrophenol was far more acutely toxic than other important nitrophenol derivatives. It was able to uncouple oxidative phosphorylation by suppressing the coupling of electron flow to synthesis of adenosine-triphosphatase. It caused weakness, intense thirst and sweating, increased body temperature and respiration rate, neuritis, convulsions, and the rapid onset of rigor mortis after death. It has also caused cataracts in humans when used as a weight reducing aid. Inhalation of 2,4,6-trinitrophenol has caused considerable irritation to the eyes and to the mucous membrane of the respiratory tract. Dermal exposure has produced severe skin irritation and sensitization.
NIOSH-Contract; Contract-210-79-0030; Fungicides; Preservatives; Explosives; Toxic-effects; Nitro-compounds; Mutagens; Skin-exposure; Eye-irritants;
88-75-5; 554-84-7; 100-02-7; 51-28-5; 88-89-1;
NTIS Accession No.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-536, Second Draft