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Information profiles on potential occupational hazards: organic anhydrides.

Authors
Anonymous
Source
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-635, Second Draft 1982 Feb; :1-126
Link
NIOSHTIC No.
00188277
Abstract
Information profiles were presented on the following organic anhydrides by virtue of their importance in the industrial community: acetic-anhydride (108247), butyric-anhydride (106310), citraconic-anhydride (616024), dodecenylsuccinic-anhydride (25377735), isobutyric-anhydride (97723), maleic-anhydride (108316), phthalic-anhydride (85449), propionic-anhydride (123626), pyromellitic-dianhydride (89327), succinic-anhydride (108305), tetrahydrophthalic-anhydride (85438), and trimellitic-anhydride (552307). The organic anhydrides appeared to be moderately toxic with median lethal dose levels for rats ranging from 697 to 2600mg/kg. The maleic, phthalic, acetic and trimellitic anhydrides appeared to be the most acutely toxic of the group discussed. All were irritants to the skin, eyes, and respiratory tract. Injection site tumors have occurred following administration of succinic and maleic anhydrides. Limited evidence suggested teratogenic potentials for acetic, maleic, phthalic, and succinic anhydrides.
Keywords
NIOSH-Contract; Contract-210-79-0030; Metal-finishing; Resins; Plasticizers; Agricultural-chemicals; Toxic-effects; Teratogens; Carcinogens
CAS No.
108-24-7; 106-31-0; 616-02-4; 25377-73-5; 97-72-3; 108-31-6; 85-44-9; 123-62-6; 89-32-7; 108-30-5; 85-43-8; 552-30-7
Publication Date
19820201
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1982
NTIS Accession No.
PB89-216618
NTIS Price
A08
Identifying No.
Contract-210-79-0030
Source Name
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-635, Second Draft
State
NY
Page last reviewed: June 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division