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Information profiles on potential occupational hazards: phthalates.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-520, Second Draft 1982 Mar; :1-147
Information profiles were presented for the following phthalates deemed to be significant based on their annual production quantities: butyl-benzyl-phthalate (85687), diallyl-phthalate (131179), di-n-butyl-phthalate (84742), di-2-ethylhexyl-phthalate (117817), diethyl-phthalate (84662), diisodecyl-phthalate (26761400), diisononyl-phthalate (28553120), dimethyl-phthalate (131113), ditridecyl-phthalate (119062), and diundecyl-phthalate (3648202), N-hexyl-N-decyl-phthalate (25724587) and mixed dialkyl (C7 to C11) phthalates. In general the phthalates had a low order of acute toxicity. Histological damage to the lungs, liver and kidneys was associated with acute oral and/or intraperitoneal exposures to some of the compounds. Others have caused slight skin and eye irritation. Repeated oral exposure to many of the esters resulted in liver and/or kidney damage. Butyl-benzyl-phthalate and di-2- ethylhexyl-phthalate induced development of leukemia in rats and hepatocellular carcinomas in mice, respectively. Ingestion of di-n- butyl-phthalate in humans caused nausea, dizziness, photophobia, lacrimation and conjunctivitis. Patients receiving blood stored in polyvinyl-chloride bags that contained residual di-2-ethylhexyl- phthalate suffered a respiratory distress syndrome called shock lung. Neurological effects have been reported in workers exposed to a mixture of phthalate esters in production vapors. Epidemiological studies of di-2-ethylhexyl-phthalate showed no adverse health effects.
NIOSH-Contract; Contract-210-79-0030; Plasticizers; Coatings; Adhesives; Insecticides; Resins; Solvents; Toxic-effects; Carcinogens; Occupational-exposure; Epidemiology
85-68-7; 131-17-9; 84-74-2; 117-81-7; 84-66-2; 26761-40-0; 28553-12-0; 131-11-3; 119-06-2; 3648-20-2; 25724-58-7
Final Contract Report
NTIS Accession No.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 82-520, Second Draft
Page last reviewed: June 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division