Information profiles were presented for the following epoxy compounds deemed to be significant due to their commercial importance: n-alkyl-glycidyl-ethers, allyl-glycidyl-ether (106923), 1,2-butylene-oxide (106887), butyl-glycidyl-ether (2426086), 1,2- epoxy-hexadecane (7320378), ethylene-oxide (75218), 2-ethylhexyl- glycidyl-ether (2461156), glycidol (556525), glycidyl-acrylate (106901), glycidyl-methacrylate (106912), and propylene-oxide (75569). The median lethal toxicity value in rats for these compounds ranged from 232mg/kg for glycidyl-acrylate to 17100mg/kg for n-alkyl-glycidyl. Most of the compounds were mild to moderate skin and eye irritants. Ethylene-oxide was shown to be teratogenic in mice when given by intravenous injection, but not in rats exposed by inhalation. Several of these compounds demonstrated positive mutagenic responses. Butylene-oxide and glycidyl-methacrylate caused no increase in tumors after administered dermally and by gavage, respectively. Ethylene-oxide demonstrated a weak positive response in a carcinogenicity bioassay. A positive carcinogenic result was obtained for 1,2-epoxyhexadecane in a skin painting study. Propylene-oxide produced tumors at the site of injection following subcutaneous administration.
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