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Information Profiles on Potential Occupational Hazards: Chlorophenols.

Anonymous

Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-532, Second Draft 1981 Mar:138 pages

00188264

Information profiles were presented on the following compounds: 2- chlorophenol (95578), 3-chlorophenol (108430), 4-chlorophenol (106489), 2,4-dichlorophenol (120832), 2,5-dichlorophenol (583788), 2,6-dichlorophenol (87650), 2,3,6-trichlorophenol (933755), 2,4,5- trichlorophenol (95954), 2,4,6-trichlorophenol (88062), 2,3,4,6- tetrachlorophenol (58902), and pentachlorophenol (87865). Studies have indicated that, administered in acute lethal doses, the chlorophenols produce excitation and increased respiration followed by motor weakness, hypotonia, convulsions, coma and death. All chlorophenols are well absorbed dermally, and toxic to skin and eyes. Workers exposed to 4-chlorophenol have demonstrated signs of functional disorders of the central and peripheral nervous systems and mucous membrane structure. Tumor development has been promoted in mice exposed to 2,4-dichlorophenol which was nonmutagenic in the Ames assay and produced abnormal fetuses in mice. 2,4,5- Trichlorophenol has caused liver and kidney damage, has promoted the development of papillomas when applied dermally to mice, and is an irritant to the eyes, skin, nose and throat of humans. 2,4,6- Trichlorophenol administered orally has increased the incidence of lymphomas and leukemia in male rats and leukocytosis and monocytosis in rats. Testing in mice has produced increased incidences of hepatocellular carcinomas, adenomas, hepatomas, and reticulum cell sarcomas. Studies of 2,3,4,6-tetrachlorophenol have shown no carcinogenic potentials, mutagenic activity, or teratogenicity of the compound; there were signs of fetotoxicity in rats.

NIOSH-Contract; Contract-210-79-0030; Chlorinated-hydrocarbons; Preservatives; Laboratory-animals; Carcinogens; Resins; Pigments; Disinfectants; Herbicides; Bactericides; Fungicides;

95-57-8; 108-43-0; 106-48-9; 120-83-2; 583-78-8; 87-65-0; 933-75-5; 95-95-4; 88-06-2; 58-90-2; 87-86-5;

19810301

Contract;

1981

PB89-216220

A08

Contract-210-79-0030

Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, SRC TR 81-532, Second Draft

NY;