Effect of Varying Doses of UVB and UVA on Mammalian Skin.
NIOSH 1982 Apr:736-767
A systematic study using Sk-1-hairless-mice was made of the dependence of squamous cell cancer development on ultraviolet (UV) wavelength distribution, total dose, and dose fractionation in a manner simulating solar radiation at various stages of ozone depletion. Measures were made of the rate of squamous cell cancer induction in 6 week old mice following chronic exposure to solar simulating radiation (SSR) from a 1.6 kilowatt Xenon arc lamp passed through Schott WG-320 filters of 0 to 3 millimeter thicknesses. Other experiments determined the effects of relatively narrow band UV radiation on the development of squamous cell carcinoma in hairless-mice. The findings suggested that photocarcinogenesis is a dynamic process with no simple relationship existing between erythema and tumorigenic responses, nor is there a simple relationship between spectral distribution with possible waveband interactions, total dose, and dose fractionation as they relate to tumor production. The authors recommend that research be conducted in the area of manmade ozone depletion and its effects on squamous cell cancer incidence. Efforts should also be made to gauge the effects of such factors as immunologic surveillance and chemical cocarcinogens on ultraviolet photocarcinogenesis.
Ultraviolet-radiation; Radiation-exposure; Skin-exposure; Laboratory-animals; Skin-cancer; Nonionizing-radiation;
Proceedings of the Second NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, September 9-11, 1981, Rockville, Maryland