Effects of Carcinogens, Mutagens, and Teratogens on Non-human Species (Aquatic Animals).
NIOSH 1982 Apr:687-720
Studies were conducted of aquatic systems and organisms both under field and laboratory conditions to develop indicator, screening, and modeling capabilities for the detection and evaluation of carcinogens, mutagens, and teratogens. Emphasis was placed on the development and utilization of critical life stage exposures to minimize the time required to obtain a tumorigenic response. Long term exposures of fish to herbicides indicated that boney growths were accompanied by enlarged and histopathologic changes of the pituitary. Tiger-salamanders may be good biochemical and histologic indicators of the presence of certain carcinogens. Field monitoring of mollusks and carcinogenic polycyclic aromatic hydrocarbons (PAH) of the Oregon coast suggested a positive correlation between cellular proliferation disorders in shellfish and certain PAHs in the natural waters. The elucidation of the metabolism of the mixed function oxidases in marine organisms suggested that fish have metabolic pathways similar to mammals for the disposition of certain carcinogens. Methods to determine possible binding of proximal carcinogenic metabolites to DNA's of selected aquatic animals have been sought. Included in this report were summaries of progress made in cooperative agreements dealing with the development of a carcinogen assay system using estuarine fishes, the use of rainbow- trout as models for environmental carcinogenesis, causes of papillomas on fish living in chlorinated sewage effluent, environmental perylene (198550) as a possible carcinogen, carcinogens and neoplasia in indigenous populations of aquatic organisms, oxidation and conjugation of carcinogenic hydrocarbons in marine animals, and metabolism of polyaromatic hydrocarbons in marine organisms.
Metabolic-study; Biological-monitoring; Chlorinated-hydrocarbons; Enzyme-activity; Environmental-pollution; Nucleic-acids; DNA-damage; Animal-studies;
Proceedings of the Second NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, September 9-11, 1981, Rockville, Maryland