Determining the Role of Pulmonary Fibrosis in the Etiology of Lung Cancer.
Lewis-TR; Eldridge-SR; Renne-RA
NIOSH 1982 Apr:463-482
The work accomplished during the first phase of a joint project between NIOSH and the National Cancer Institutes was reported; the project was to develop an experimental model to test the hypothesis that pulmonary fibrosis presents a cocarcinogenic effect in the etiology of pulmonary carcinoma. Future work will include an animal study in which simultaneous exposure was given to the fibrogenic agent and a carcinogen. During this first phase the type and extent of pulmonary fibrotic response occurring in male Syrian-golden- hamsters receiving multiple intratracheal instillations given once weekly for 15 weeks of crystalline quartz (14808607), fibrous glass, hydrated alumina (21645512), or a 1:1 mix of ferric-oxide (1309371) and crystalline quartz was determined. There were 18 treatment groups of four animals each receiving treatment at four dose levels; two groups served as controls. An overall 58 percent mortality rate was noted by the end of week 82. Amyloidosis was the cause or a contributing cause in the deaths of many of the hamsters. Increased mortality was noted for animals receiving the two higher doses of quartz and quartz plus ferric-oxide. Animals receiving all dose levels of alumina and fibrous glass had mortalities similar to control animals. Decreased body weight was noted at the highest treatment dose of each treatment group.
NIOSH-Author; NIOSH-Contract; Contract-210-79-0038; Silica-dusts; Mineral-dusts; Pulmonary-system-disorders; Carcinogens; Hexavalent-chromium-compounds; Asbestos-dust; Laboratory-animals;
14808-60-7; 21645-51-2; 1309-37-1;
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
Proceedings of the Second NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, September 9-11, 1981, Rockville, Maryland