Carcinogenic Potential of Condensed Pyrolysis of Effluents from Iron Foundry Casting Operations.
Moorman-WJ; Palmer-WJ; Mulligan-LT
NIOSH 1982 Apr:445-462
The carcinogenic potential of pyrolysis effluents was examined as they were generated during molding and pouring operations at iron foundries. Emissions were studied from the four most commonly used binders including furan (110009), urethane (51796), shell and green sand. Samples collected from the casting molds shortly after they were poured consisted of a water soluble fraction and a particulate fraction which was insoluble in water. A wet venturi scrubber was used to collect source samples from molds shortly after they were poured. In each sample the concentration of eight polycyclic aromatic hydrocarbons and 16 metals was determined. The ability of the emissions from these samples to cause cancer in Syrian-golden- hamsters via intratracheal instillation was evaluated. First a 6 week range finding study was conducted, followed by a chronic carcinogenicity assay. Bioassays indicated similar acute toxicities for the green sand, furan, and shell molds. The urethane samples were significantly more toxic, resulting in the determination of a maximum tolerated dose of one half of that for the other mold samples. The maximally tolerated dose levels will be administered repeatedly to animals for a period of time deemed sufficient to produce cancer if chemical carcinogens are present in significant enough quantities.
NIOSH-Author; NIOSH-Contract; Contract-210-78-0033; Carcinogens; Foundry-workers; Pyrolysis-products; Pulmonary-system-disorders; Lung-cancer; Laboratory-animals;
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
Proceedings of the Second NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, September 9-11, 1981, Rockville, Maryland