This paper reviewed background information concerning toluene (108883), literature reports of health effects resulting from exposure to toluene, and reasons for further studies; an update on a current study was provided. Various animal and human studies have indicated associations between toluene exposure and increased risk for anemia, leukemia, myeloid metaplasia, and chromosomal aberrations. Other studies of human exposures suggested damage to the hematopoietic system, central nervous system, and possible injury to the kidneys. A retrospective mortality study was designed to ascertain long term health risks of former workers exposed to toluene through work in the shoe making industry. The study cohort includes almost 10,000 white females employed sometime between 1940 and 1977 in two shoe making facilities located in the midwest. Data analysis will include factors such as time from exposure to the development of disease, length of employment, age at the start of employment, and job category. Previously reported health problems in this industry have included nasal cancer, gynecological disorders, and noise and vibration exposures.
Proceedings of the Second NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, September 9-11, 1981, Rockville, Maryland